through all or selected combinations of the three models, and 3) printouts of graphics. The final 
phase is establishment of a user-fnendly Windows version of the ACE software. This will be a 
joint effort with the University of Missouri, Columbia, MO, throu^ a cooperative agreement 
funded by ORD/NHEERL, OW, and OPPTS. 
For selected classes of chemicals, the utility of estimating WQC values based on limited data will 
be examined by applying extrapolation techniques to subsets of data for existing WQC. This 
exercise will provide insights into the accuracy and margin of error that might be expected by 
such extrapolations. 
Products 
FYOl Report on sensitivity of threatened and endangered fishes to contaminants with 
comparisons to that of standard surrogate species. 
APM 4A FY02 ICEs for acute toxicity to aquatic organisms (GED). 
APM 4B FY02 Time-concentration-effect models for use in predicting chronic toxicity from 
acute toxicity data (GED). 
APM 4C FY03 Acute to chronic estimation (ACE) user guide and software (GED). 
FY06 Refinement of ICEs for acute toxicity to aquatic organisms based on new data. 
Benefits of Products 
Research products developed under this plan will provide managers with extrapolation methods 
and guidance to use when making decisions based on limited data sets. Specifically, 1) 
interspecies correlations will allow the user to estimate the acute toxicity for a species having no 
data ^m a common test species having acute data and 2) ACE allows prediction of chronic 
toxicity using only acute toxicity data. Estimates for both acute and chronic endpoint predictions 
include measures of accuracy and uncertainty. 
(Note : Because of resource reductions after the initial development of this plan, 
the following project will not be pursued at this time.) 
Project Title N3, Assessing the Significance of Non-Equilibrium Conditions on Sediment 
Guidelines to Better Predict Field Effects 
Project Coordination and Resources (3.0 FTEs: AED-3.0) 
Objectives 
The majority of U.S. EPA’s sediment guidelines are based on the assumption that equilibrium 
conditions exist (EPA 2000a,b,c,d). This assumption may be one of the largest weaknesses in 
these guidelines. In the laboratory, where many guidelines are developed, this assumption is 
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