FY05 Journal article or internal report on bioaccumulation of PAHs by fish during early life 
stages of development. 
FY06 Journal article on model/s (including PB-TK) for prediction of bioaccumulation by fish 
during early life stages of development 
Benefits of Products 
The overall benefit is anticipated improvements in bioaccumulation measurements, models, and 
site-specific af^licability, coupled with conceptual clarification of howto incorporate multi- 
media exposure relationships (water, sediment, food chain) into application of chemical residue- 
based toxicity data for development of WQCAVQS, TMDLs, or management of contaminated 
sediments. A specific benefit will be much improved capability, including guidance for sample 
collection and analysis requirements, for extrapolating measured BAFs and BSAFs between 
ecosystems. The capability to provide species and chemical specific rates of metabolism for food 
chain model predictions of bioaccumulation will be a significant improvement since many PBTs 
have reduced bioaccumulation in parts of the food web due to metabolism. Practical and 
beneficial combinations of empirical and mechanistic modeling methods will be defined to 
increase both ease and accuracy of bioaccumulaticHi predictions for site-specific criteria and risk 
assessment applications. Also expected is demonstration of the integration of the basic 
bioaccumulation models with toxicokinetic models as required for PBT criteria and risk 
assessments involving particular modes of action and critical effect end points. 
Project Title B3. Multiple Stressor Risks to Common Loon and Other Piscivorous Bird 
Populations (cross-listed in Section 4, Habitat Alteration, Project 4) 
Project Coordination and Resources (6.9 FTEs: AED-5.4, MED-1.5) 
Objectives 
This project has been developed as a demonstration and evaluation of the utility of the research 
approaches described in NHEERL’s WRS (EPA 2000e). The wildlife strategy describes research 
approaches that address key research needs, including improved capabilities for cross-species 
extrapolation, prediction of population dynamics in spatially-explicit habitats, assessment of the 
relative risk of chemical and non-chemical stressors, and definition of appropriate spatial scales 
for wildlife risk assessments. This project is one of several that will be developed to evaluate the 
approaches and key hypotheses regarding risks to wildlife species that are described in the 
wildlife strategy. In addition to its consistency with these overall objectives, this specific project 
was identified because it involved minimal data collection activities and addressed a problem of 
immediate concern to the Agency. 
The overall objective of this demonstration project is to develop the tools and approaches for 
assessing the risks of multiple stressors to populations of piscivorous wildlife, leading to the 
development of risk-based criteria. Three major research objectives include: 
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