50 
2. There is a terminal infection with the 
diplococcus pneumoniae. 
Spleen .—The trabeculae of the pulp are distended 
by infected red cells, and pigmented large mononu¬ 
clears are abundant. The malpighian follicles, on the 
contrary, are non-pigmented. 
Liver .—Endothelium of capillaries is swollen and 
pigmented. Pigment is also found in Kupfer’s cells. 
The liver cells contain only haemosiderin, not melanin. 
Pigmentation is most intense around the central veins. 
Fig. 13. Shewing deposition of Pigment in Liver {left), 
Spleen {right), and Sporulating Parasites in 
Brain Capillary {bottom) 
Kidneys .—Pigmentation is much less marked. 
Changes may occur in the epithelium of the tubules, 
independent of the presence of parasites. 
Bone Marrow .—Parasites and melanin, free, and 
in large mononuclear leucocytes, and macrophages are 
found. Crescents may be found here when absent 
of scanty elsewhere, as in the spleen and brain ; it is 
consequently supposed that they principally develop 
here. 
