5i 
In cases of malaria of long standing the yellow 
marrow becomes red. 
Stomach and Intestines .-—In malaria with choleraic 
or haemorrhagic symptoms, parasites may abound in 
the capillaries of the villi. 
Chronic Malaria 
Spleen .—As is well known, the spleen may in 
these cases fill the whole abdomen. Dilatation of the 
various lacunae occurs with a thickening of the splenic 
reticulum. The pigment tends to become deposited 
eventually in the connective tissue surrounding the 
follicles. The splenic septa become thickened. 
Liver .—-The pigment is found mainly in the 
periphery of the lobules, and pigment in the form of 
blocks in the perivascular connective tissue. 
The capillaries are much dilated, and the epithe¬ 
lium contains blocks of pigment. Atrophy of the liver 
cells and their nuclei occurs. 
Bone Marrow .—The marrow of the long bones 
is usually red, due to a large development of haemato- 
blastic tissue. Normoblasts are common. 
Pigment disappears rapidly from the bone marrow. 
LITERATURE 
Marchiafava and Bignami. Twentieth Century Practice oj 
Medicine. Malaria. Vol. XIX. S. Low, Marston and Co. This 
comprehensive and learned treatise is incomparably the best in the 
English language, dealing with all aspects of malaria and also black- 
water fever. 
