2 43 
leucocytes, as these, as also in ordinary malaria, may 
require long search. 
10. Make careful differential counts of the 
leucocytes, especially when the temperature is falling, 
as it is then that the mononuclear increase is most 
marked. When the temperature is raised (e.g . 9 103° 
to 105°) the polynuclears may reach ninety per cent. 
11. Observe presence of normoblasts, megalo- 
blasts, various abnormal staining reactions, e.g., poly- 
chromasia of the red cell, especially during recovery. 
12. Make careful blood counts immediately 
before and after administering quinine when no haemo- 
globinuria results. According to Panse there may 
result a blood destruction due to the quinine, which 
does not shew itself as haemoglobinuria. 
Microscopical investigations in this disease are 
frequently negative as regards malaria parasites, but 
it is all important when the examination is made, as 
the following analysis of over one hundred cases 
microscopically examined shows :— 
Author 
Day before 
Haemoglobinuria 
Day of 
Haemoglobinuria 
Day after 
onset 
No. of 
Cases 
No. 
Positive 
1 No. of 
1 Cases 
No.- 
Positive 
No. of 
Cases 
No. 
Positive 
A. Plehn . 
5 
5 | 
5 
3 
10 
2 
F. Plehn . 
0 
0 
21 
18 
10 
3 
Koch . 
Stephens and 
. 5 
5 
8 
6 
6 
I 
Christophers 
1 
1 
9 
2 
16 
O 
Daniels ... . 
3 
3 
3 
1 
2 
0 
Panse 
9 
8 
1 7 
9 
20 
5 
Total . 
2 3 
22 
63 
39 
64 
11 
Percentage Positive 
95*6 per cent.j 
61*9 per cent. 
17'1 per cent. 
