245 
Urobilinuria 
As we have indicated elsewhere, the occurrence 
of urobilin may be an important indication in cases 
where a susceptibility to quinine haemoglobinuria 
exists : thus, in Murri’s case, a girl had haemoglo¬ 
binuria eight times between August 3, 1894, and April 
6, 1895, following upon the administration eight times 
of small doses of quinine. From 1895 to 1897, the 
girl remained well. On March 27, 1897, she was 
given 0*5 gramme of quinine, to see whether her 
disposition to quinine poisoning still remained. The 
result was fever, vomiting of bile, etc., albuminuria, 
peptonuria, and urobilinuria (not haemoglobinuria). 
A. Plehn, in a recent paper, points out a peculiar 
property of the urine sometimes observed in blackwater 
cases. On boiling the urine and allowing to stand for 
some time, a bright purple colour appears. 
We have observed that blackwater urines made 
alkaline with potash, and then boiled produce a purple 
colour, giving the bands of haemochromogen (reduced 
haematin), shewing that the urine itself contained 
reducing bodies. 
Whether Plehn’s purple colour is the same we 
cannot say. 
Post-Mortem Examination 
1. Make smear preparations of spleen, kidney, 
liver, bone marrow, brain, etc. Examine for parasites 
and pigmented leucocytes. Parasites are generally 
absent, but pigmented leucocytes may occur in large 
numbers in the spleen. Fine pigment is also found in 
the liver in endothelial capillary cells. (Fig 13). 
2. Cut sections, especially of brain tissue, as 
parasites may be found in the capillaries and nowhere 
else. 
