246 
Spleen. —Malarial pigment (melanin) occurs in large mononuclear 
cells and in giant cells (macrophages). Melanin may also occur in the 
stroma or even beneath the capsule. 
Liver. —Melanin occurs in endothelial cells, and especially in 
macrophages. Yellow pigment (haemosiderin) occurs in the liver 
cells, also, to a certain extent, in the same situations as melanin. Apply 
the iron reaction ( vide Appendix) to the sections. Haemosiderin 
gives the blue colour, melanin does not. 
Kidney. —Necrosis and desquamation of the epithelium of the 
convoluted tubes. The straight tubules are blocked with masses of 
granular matter, staining dark red with eosin. Interstitial nephritis 
usually not present. 
Bone marrow. —Evidence of malarial infection (pigment). Pro¬ 
liferation of normoblasts (cp. p. 49). 
LITERATURE 
Twentieth Century Practice of Medicine. Malaria , by Marchiafave 
and Bignami. The fullest and best account in the English language. 
Allbutt and Rolleston. Vol. II, pt. ii. Blackwater Fever , or 
Osier’s Modern Medicine. Vol. I. Blackwater Fever. 
