347 
anaemia and weakness ; (3) The most characteristic 
symptom is paralysis of the hind quarters. This first 
shews itself in a dragging of the hoof, and progresses 
until the animal can no longer stand ; (4) Haemo- 
globinuria is not uncommon ; (5) Oedema is rare ; 
(6) Eye symptoms also occur. 
The disease is nearly always fatal, and lasts a few 
days, weeks, or months. In donkeys the disease is 
chronic, lasting six to twelve months. Cattle, goats 
and pigs are very refractory to inoculation. 
Blood Examination.—-Trypanosomes are most 
easily found during the pyretic periods. A sub¬ 
inoculation into a dog or rabbit is often necessary 
for the detection. 
Morphology. —22-24/* by 1 ‘ 5 ^- The main charac¬ 
teristic is the extremely small (? existent) blepharo- 
plast. 
Pathology. —The spleen is much enlarged, also 
the liver and lymphatic glands. The kidneys shew 
haemorrhagic nephritis. Effusions occur in the 
various serous cavities. 
Transmission. —The mode is unknown. It is 
possible that ticks are concerned, for the evidence 
is rather against biting flies. 
Zousfana. —Is possibly a variety of T. equinum. 
It affects horses in Algeria. Oedema is nearly always 
absent, and attacks of haemoglobinuria lasting 
one to two days are common. 
5. T. equiperdum. —The cause of Dourine, a 
disease of horses in Europe, N. America, Algeria 
(especially), India. 
Symptoms. —Three periods are described :— 
(1) Period of oedema :—Eleven to twenty days 
after coitus, swellings of the genitalia appear. There 
is also fever. 
