374 
Histoplasma Capsulata (Darling, 1906) 
This parasite was found in enormous numbers in 
the tissues in a patient in Panama. 
The Lungs shewed a condition closely resembling 
miliary tubercle but the nodules consist of broken 
down alveoli containing epithelial cells distended with 
parasites. 
The Liver is enlarged. The liver cells and 
endothelium of the portal capillaries are invaded by 
myriads of parasites. 
Fig. 114. Histoplasma capsulata: intr a corpuscular forms from a 
smear of lung tissue , and free forms expressed from the cells 
The Spleen is enlarged (x 3) and firm. It con¬ 
tains many parasites. 
Lymphatic Glands .—The mesenteric and splenic 
glands are enlarged, and parasites occur in mononuclear 
cells. 
The Parasite is about half the diameter of a red 
cell. It is round or oval and is surrounded by a refrac¬ 
tive rim. The parasite has a large and small staining 
mass. It is mainly an intracellular parasite. Whether 
it occurs in the blood is unknown. 
