it 10 tne same pauemau * ^uun.otcicu 
observing any beneficial effect, and whose case, in reference to tins agent, 
I mentioned in the Lancet a few weeks ago. The man, a middle-aged 
person, was passing, under a restricted diet, about six pints of urine, con¬ 
taining upwards of three thousand grains of sugar, in the twenty-four 
hours. At first, after the ozonic ether had been discontinued, morphia 
was administered in gradually ihcreasing doses, beginning with half a 
grain three times a day. The quantity of urine and sugar from day to 
day declined, and, in the space of about three weeks, disappeared alto¬ 
gether; the quantity of morphia administered at this time being a grain 
and three-quarters three times a day. After a little while, the morphia 
was taken off; and in a week’s time the sugar began to reappear, and 
went on from day to day increasing. This state of things was allowed to 
continue for about a fortnight, when opium was given ; and, under its in¬ 
fluence, the sugar has again disappeared. I merely here allude to this 
case; the patient, being still in the hospital, may be seen by any one 
desirous of doing so. 
Of what service as a curative agent, opium, in larger doses than it has 
been customarily given, may prove in cases in general, I do not at present 
pretend to say. Much more extended observation is required before this 
point can be determined. Whatever may happen to be disclosed by sub¬ 
sequent experience, it cannot be denied, I think, that we have before us 
an important therapeutic fact. 
Missoum Dcn vwr*. p, 
George Engelham. p a 
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