ABSORPTION OF VIRUSES. 
635 
TO FIND OUT HOW LONG AFTER INOCULATION IT IS PRAC¬ 
TICABLE TO DESTROY OR REMOVE THE PORTION OF SKIN UNDER¬ 
NEATH THE EPIDERMIC COVERING OF WHICH EITHER VIRUS HAS 
BEEN INSERTED, SO AS TO PREVENT OR SENSIBLY DIMINISH ITS 
GENERAL OPERATION. 
1.— Experiments on the Absorption of Glandered Virus. 
Thirteen horses were submitted to experiments with glandered 
virus. 
In the first and second, a flap of skin was excised, of the size of 
a halfcrown piece, around the part inoculated, ninety-six hours 
after inoculation, and immediately after the wound was well cau¬ 
terized. Both horses died of acute glanders; one in twelve days, 
the other in eight days after inoculation. 
The third horse, cauterized fifty hours after inoculation, died of 
acute glanders nine days afterwards. 
The fourth horse, cauterized twenty-four hours after inoculation, 
died of acute glanders seven days afterwards. 
The fifth, cauterized ten hours after inoculation, died of acute 
glanders nine days afterwards. 
The sixth, cauterized eight hours after inoculation, died of acute 
glanders six days afterwards. 
The seventh, cauterized six hours after inoculation, was destroyed 
on the twentieth day afterwards, exhibiting unequivocal symptoms 
of sub-acute glanders. In the lungs, glands, and lymphatics 
around the inoculated part were found characteristic lesions of 
the disease. 
The eighth, cauterized five hours after inoculation, died of acute 
glanders twenty-one days afterwards. 
The ninth, cauterized four hours after inoculation, died of acute 
glanders seven days afterwards. 
The tenth was cauterized four hours after inoculation; but, 
prior to the cauterizing, a flap of skin as large as a crown piece 
had been excised. Eighteen days afterwards this horse was de¬ 
stroyed. Autopsy shewed in the nasal cavities, lungs, and spleen, 
the lesions characteristic of acute glanders. 
The eleventh, cauterized three hours after inoculation, died of 
acute glanders fifteen days afterwards. 
The twelfth, cauterized two hours after inoculation, died of acute 
glanders fourteen days afterwards. 
Lastly, the thirteenth horse, cauterized as early as one hour 
after inoculation, died fourteen days afterwards. 
Further than this M. Renault has not pushed his experiments, 
so far as concerns the virus of glanders : he has it in contempla¬ 
tion, however, to do so at another time. 
