COLORATION OF BONES FROM MADDER. 
555 
V. The length of time between the development of the disease 
and its fatal termination . —On this point the statistics col¬ 
lected corroborate too full} 7 the preconceived ideas, as to the 
rapid progress of the disorder. Out of l6l cases, death put 
an end, within a week, to the horrible sufferings of the patients 
in 158, more than one half of that number dying within four 
days, even, from the time at which the malady first mani¬ 
fested itself. 
YI. The relative efficacy of the means employed to prevent the 
development of hydrophobia. —Upon this all-important portion 
of the subject Dr. Tardien observes that the fact cannot be 
too strongly insisted upon, that the only hopes of security 
from the fatal effects of this dreadful disease consist in 
immediate cauterization with the red-hot iron, and that 
every other method only compromises the future safety 
of the patient by the irreparable loss of the only moments 
during which the preventive treatment is applicable. 
VII. Curative treatment of hydrophobia ivhen it has become 
developed. —Dr. Tardien makes the disheartening statement, 
that of all the remedies which have as yet been suggested, 
chloroform included, for the treatment of hydrophobia when 
fully developed, he has found none to have been attended 
with sufficiently promising results to enable him definitely to 
say that it will effect a cure.— The London Medical Review. 
NOTE ON THE COLORATION OE THE BONES OE THE FOETUS, 
BY THE ACTION OF MADDER MIXED IN THE FOOD OF 
THE MOTHER. 
By M. Flourens. 
It is near twenty years since I presented to the Academy 
(Sd February, 1840) two or three skeletons of pigeons, reddened 
by the action of madder, which had been mixed for a certain 
time with the food of those animals. The last experiments 
of this kind, made in France, were by Duhamel in 1739, 
just a century before mine. The experiments of Duhamel 
being almost forgotten, mine were received with curiosity by 
physiologists. 
At the meeting of the Academy on February 24th, 1840, 
passing from my observations on birds to those of mammals, I 
presented to the Academy the skeletons of two or three puny 
pigs whose bones and teeth were completely reddened by the 
action of madder mixed with the food. 
