574 
DISEASE OF OSSEOUS TISSUE IN THE HORSE. 
the subject to him, and had also shown him the portions of 
bone which I had sent; and as the disease presented many 
peculiarities of an unusual character, they were both very 
desirous of investigating its pathology more fully, and for 
this purpose he expressed a wish to be furnished with other 
specimens. As pathological anatomy is more especially 
within the province of Dr. Harley, this, no doubt, was the 
reason of Dr. Sharpey placing the matter chiefly in his hands. 
On the 9th of January I received from Dr. Harley the 
following letter: 
77, Harley Street; 
9th Jan., 1860. 
My dear Sir, —Professor Sharpey and I have examined the bones, and 
find that their microscopic structure is peculiar; so much so, indeed, that we 
think the subject worth bringing under the notice of the Pathological 
Society, if you do not object to such a course, and would kindly furnish me 
with the history of the cases. 
One thing we should like particularly to know, viz., if the animals are 
all the offspring of the same parents; if the mares are likewise affected, and 
if they were stall-kept, or at large. 
Very truly yours, 
George Harley. 
I not only readily consented to the matter being laid be¬ 
fore the Pathological Society, but was pleased to find that it 
had excited so much attention; and therefore I wrote an 
affirmative to this request, and, at the same time, gave 
Dr. Harley a brief history of the horses that had been the 
subjects of the disease, as well as of those now affected. 
On the 13th of January I received the following letter: 
77, Harley Street; 
13 th Jan., 1860. 
My dear Sir, — I have perused with much pleasure your interesting 
letter and answers ; but there are still two or three points which I should 
like to have definite information on. 
1st. Was the disease accompanied by any signs of pain, and in what time 
did it appear to run its course ? 
£ 2d. Hid the horses get the same amount of exercise as the mares, and are 
there other horses on the same farm that are still free from the disease ? 
3d. In what county are the farms; how far are they apart; and are there 
any factories or chemical works in the neighbourhood? 
Would you also, at the same time, send me a small fragment of healthy 
bone from the outside of the ramus of a horse’s jaw, in order that I may 
compare its structure with that of the diseased bone from the same locality ? 
Yery truly yours, 
George Harley. 
Before replying to this letter I wrote to Mr. Champion, 
and received the following reply: 
