W. L. Yakimoff and others 
57 
2-nuclears .. 
3- 
4- 
5- 
6 - 
5 ? 
5 ? 
2M % 
38-7 
29-9 
7-1 
3-8 
Binuclears. During the first two or three days following infection there 
was a slight decrease in percentage, but beginning from the 5th day a pro¬ 
gressive rise of the curve was observed, which rose higher and higher, reaching 
on the 21st day the maximum of 50*6 %. 
With one or two exceptions a somewhat high proportion was maintained 
until the death of the animal. 
Trinuclears. Already on the 3rd day after infection these tended to 
increase, and on the 43rd day reached the maximum (62*5 %). Several days 
later the curve began to fall, sometimes reaching the primary average, and 
even falling below; but 10 days before death it again rose (44-58-6 %) and 
remained so until death occurred. 
In general, the curves of the bi- and trinuclears stand in inverse relations 
to each other. 
Tetranuclears. These rose slightly on the second day after infection, but 
later during the whole period of disease they were below the normal, reaching 
4-1 %, and further, although the curve rose sometimes, it never reached the 
normal. Only once (34th day) there was a sudden rise, when the curve reached 
42-8 %, but the very next day it fell to 13-6 %. 
Pentanuclecirs . Also increase slightly on the 3rd day after infection (to 
12-1 %), but later during the whole period of disease they were below the 
normal, sometimes even altogether absent. 
Hexanuclears. These follow the same order as the preceding polynuclears, 
whilst their disappearance from the blood is more definitely shown. 
Summarising the changes in the Arneth index, we observe the following: 
First 'period. On the first 2-3 days following infection there was a tem¬ 
porary decrease in binuclear polynuclears, the beginning of a rise of the 
trinuclears, and a slight rise of the tetra-, penta-, and hexanuclears. 
Second period , the longest, terminating with the death of the animal, is 
characterized by the following: from the 5th day the percentage of the 
binuclears begins to rise; the trinuclears continue to rise; the tetra-, penta-, 
and hexanuclears remain below the normal and the 5- and 6-nuclears dis¬ 
appear from the blood at times. 
Thus, the phenomenon took place known as the “shift to the left,” 
termed “ anisocytosis ” by Arneth. 
Therefore, comparing the alterations in the total number of leucocytes 
and in the Arneth index, the first period should be called isohypercytosis, and 
the second anisohypercytosis. 
The destruction of leucocytes commences from the second day after in- 
