72 
Trypanosomiasis of Camels 
Oedemata of the subcutaneous connective tissue of the neck, beginning of 
breast and one articulation; infiltration of yellow colour under the pleura of 
the anterior part of the thoracic cavity, on the peiicardium, transverse sulcus 
of the heart muscle and the intermaxillary, space ; exudation in thoracic and 
peritoneal cavities; and emaciation. 
The data obtained by dissection of the young pig are as follows: 
Emaciation in the subcutaneous connective tissue, no oedemata are present; the lymphatic 
glands of the lower jaw are somewhat enlarged, compact, with a reddish tint. In the 
thoracic cavity there is a serous exudation amounting to one table spoonful; in the lungs 
there are several compact foci about the size of a pea of gray-red colour; in the pericardium 
there is about one table-spoonful of yellowish exudation; in the peritoneal cavity there are 
about 1A table-spoonfuls of light yellow exudation. The spleen is enlarged (17-18 cm. 
diameter), compact, under the capsule are visible protuberances slightly yellower than the 
remaining tissue, hardly protruding above the surface. In the remaining organs no 
anomalies are visible. 
Thus the pig exhibited the following phenomena characteristic of trypano¬ 
somiasis: emaciation ; lymphatic glands somewhat enlarged; in the thoracic and 
peritoneal cavities, and in the pericardium, the presence of exudation; the 
spleen enlarged, compact. 
The dead goose exhibited no changes. 
XIII. CHEMOTHERAPY 1 . 
In the experiments on the treatment of experimental trypanosomiasis in 
camels, we have tested the following drugs: 
1. From the arsenic group : atoxyl, arsenosolvin, salvarsan, tartarus 
stibiatus (potassium stibiate) and trixidin. 
2. From the benzidine group: trypan-blue and dianil-blue (or trypanil). 
The experiments were carried out by us so as to determine first the dosis 
toxica, and then the dosis tolerata of the drug employed. 
Then on the first day of the appearance of trypanosomes in the blood, 
the infected mice were injected with a solution of the drug, the strength of 
the solution being estimated so that each mouse received 1 c.c. per 20 gm. 
live weight. Injection was carried out intravenously with all the preparations, 
except trixidin. 
Inoculations were made with the virus of Bokhara camels invigorated 
by passage through mice, the incubation period lasting at the most two days, 
and death taking place 3 days after the appearance of trypanosomes in the 
blood. 
Experiments with atoxyl. The atoxyl employed was made by the Aktien 
Gesellschaft, Charlottenburg. 
The results of the tests on the toxic qualities of the preparation are seen in 
the following table. 
1 By W. L. Yakimoff and W. T. Wasilewakv. 
