W. L. Yakimoff and others 
77 
Table 23. 
Solution 
Dose in grammes 
per 20 gr. weight 
Results 
1 
2000 
0-0005 
Not cured 
1 
1500 
0-00060 
99 
1 
1200 
0-0008 
9 9 
1 
1000 
0-001 
Cured 
1 
800 
0-00125 
99 
1 
500 
0-002 
99 
1 
250 
0-004 
91 
1 
100 
0-01 
99 
The same is seen with fuller details in the next table (Table 24). 
Table 24. 
Days 
No. of mice 
l 
2 
3 
4 
5 6 7 
Solution of 
458 
+ f.® 
+ + 
+ + 
+ + 
■j" *4" 4“ + + + death 
l : 2000 
463 
+ ® 
+ + 
+ + 
+ + + 
+ + + + 
l :1500 
518 
+ +® 
+ + 
+ + + 
death 
— — — 
l : 1200 
453 
+ © 
+ + 
+ + 
0 
examination during 48 davs. 
relapses 
No 
o 
o 
o 
p—4 
455 
+ © 
+ + 
+ 
0 
examination during 48 days, 
relapses 
No 
l: 800 
456 
+ f.® 
+ + 
+ f. 
0 
examination during 46 days, 
relapses 
No 
1:500 
459 
+ f.® 
+ + 
+ + 
0 
recovery 
1:250 
457 
+ © 
+ + 
+ 
— 
5 9 
1 : 100 
Thus, we see that the dose of 0-001 gm. per 20 gm. weight of the mouse is 
sufficient to cure it of trypanosomiasis. 
Curing by stages. Under the name of “curing by stages'" we mean the 
introduction of one and the same dose, or different doses of the preparation, 
with certain intervals of time between the successive injections. Tartar 
emetic was the first preparation to be tested, as a single injection of this 
drug cures mice only when introduced in a 1 : 1200 solution, this dose being 
close to the toxic. 
In the first series of experiments (mouse No. 306) a 1 : 5000 solution was 
injected, and after 2 days 1 : 5000 again. The animal relapsed. 
In the second series (mouse No. 324) we made two injections of 1 : 5000 
solution, and two of 1: 7000 (for intervals see Table 25). The animal relapsed. 
In the third series (mouse No. 332) we injected a 1 : 5000 solution four 
times (for intervals see table). There was recurrence. 
Thus, curing by stages with potassium antimony tartrate in small doses 
did not give any positive results. 
Atoxyl injected intravenously 2 days in succession in a 1 : 300 solution 
has driven the trypanosomes out of blood, but 9 days later there was a relapse. 
This preparation introduced in the same solution 3 days in succession, 
and also intravenously, cures the animal. 
