Trypanosomiasis of Camels 
Table 25. 
Days 
_A_ 
No. of 
mice 
f 
2 
3 4 
5 
A. 
6 
7 
8 
9 
10 
After last injection 
306 j 
f l :5000 
l: 5000 
l +v.f. 
0 
0 0 
0 
0 
0 
0 
0 
recur 
324 j 
332 -j 
fi:5000 
o 
o 
o 
o 
o 
o 
r-H 
rence 
l+f. 
' l: 5000 
0 
0 0 
0 
l: 5000 
0 
1 
0 
: 5000 
0 
0 
0 
recurrence on the 
26th day 
.+f. 
0 
0 0 
0 
0 
0 
0 
0 
0 
recurrence on the 
16 th dav 
*/ 
Table 26. 
No. of 
mice 
Days 
.... -A.. 
\ 
2 
3 
4 5 
6 
7 
8 
9 10 11 
534 
f l: 300 
1:300 
i +f. 
+f. 
0 
0 0 
0 
0 
0 
0 0 + 
535 
f l: 300 
\ +v.f. 
1:300 
+ v.f. 
l: 300 
0 
examination during 35 days. 
No recurrence 
Combined 
treatment. 
In his 
article, 
“ Chemo-therapy 
in Veterinary 
Medicine,” Yakimoff refers to the theoretical conceptions which serve as a 
basis for treatment by combinations of different preparations as established 
by Ehrlich and Laveran: 
(1) Combined treatment produces a greater effect on the parasites, as 
the action of the drugs increases with regard to the parasites, whilst it does 
not increase with regard to the organs, provided, of course, that the prepara¬ 
tions are carefully chosen. 
(2) Only quite tolerable doses of each drug are administered. 
(3) Each of the preparations affects the parasites, which are resistant 
(naturally or by habituation) against one of the preparations. Preparations 
belonging to different chemical groups should be combined, and those be¬ 
longing to one group should be of different degrees of resistance. 
(4) Methods of administration should be as varied as possible. 
We have carried out several such experiments with different preparations, 
choosing them from different groups (from the arsenic and benzidine groups). 
( 1 ) 
( 2 ) 
(3) 
(4) 
Tartar emetic + trypan-blue 
„ „ + trypanil 
Atoxyl + trypan-blue 
,, + trypanil 
- Series A. 
Further we passed from this simple combined treatment to combined 
treatment by stages on the following lines: 
(5) 
( 6 ) 
(7) 
( 8 ) 
Tartar emetic + trypan-blue + tartar emetic + trypan-blue' 
„ „ + trypanil + „ + trypanil 
Atoxyl + trypan-blue + atoxyl + trypan-blue 
,, + trypanil + „ + trypanil ; 
Series B. 
The results of our experiments are summarised in Tables 27 and 28. 
i 
