least 
William Hall Holden, M. I). 
755 Pare: Ayentje 
New York 21, N. Y 
■***<•**• 
January 12, 1950 
Dr. Alexander Wetmore 
Smithsonian Institution 
Washington 25, D.C. 
Dear Alex: 
3rd. 
I regret my delay in answering your letter of January 
0 ' 
\U 
Of course, you have the Aralen for the malaria.fi would 
certainly advise you to get a penicillin preparation known as 
Crysticillin Suspension. I would get it in the 10 cc vials, 
each cc contains 400,000 Units of Penicillin. This preparation 
is in an aqueous suspension and is easily withdrawn from the 
vial. One injection in twenty-four hours suffices for most 
types of infection that you will probably come in contact with. 
It can be withdrawn easily with either an 18 or 20 gauge needle 
and should be injected intramuscularly in the buttock, high in 
the upper, outer quadrant. If this preparation is injected too 
low in the buttock you are apt to hit one of the nerve distributions 
to the leg. This drug is a must. It will keep over a year in any 
temperature. 
As to the sulfa drugs, there are two new ones out. One is 
Gantrisin 0.5 manufactured by Hoffmann La Roche. It is supposed to 
be the least toxic of the sulfa combinations. The other is Combisul- 
D.M. manufactured by the Sobering Corp. This product is a combin¬ 
ation of Sulfadiazine, Sulfathiazole and Sulfamerizine. It is 
supplied in bottles of 100 tablets. It is used in general Infections 
and can also be used In combination with Penicillin. We sometimes 
use this combination in gram-negative and gram-positive infections 
as well as well as with some of the viruses. Either one of these 
drugs may be used in the treatment of the bacillary dysentery. 
As to the powders and oinments frankly, I am not so strong 
from them. Tincture Methiolate is always good for touching up 
scratches, cuts and insect bites. I find in the jungle the least 
amount of covering you have over wounds the better they do. If you 
have to use an ointment } plain zinc ointment after the application of 
Tincture Methiolate will do the least amount of damage. We are not 
using the sulfa drugs on wounds as much as we used to. Sulfadiazine 
powder is O.K. \ 
If there is any further information I can send you, just 
drop me a line. Kindest personal regards. 
