632 
FRANK H. MILLER. 
In speaking of this disease in the company of certain American 
medical practitioners studying at Berlin, one of those gentlemen, 
Dr. A. E. Tausig, of St. Louis, a student in the laboratory of Sal- 
kowski, expressed surprise that the disease was accounted rare 
among animals, and related to me a case which developed in one 
of his own dogs. I will quote from a written report which he 
was kind enough to give me. 
“ Male mongrel dog, about 13 years of age, no family history 
obtainable, no previous illness, took but little exercise. For 
about one year previous to his illness the thyroid gland had en¬ 
larged until it was nearly as large as one-half the closed hand, 
soft and movable. This was unaccompanied by other symptoms. 
Later polyuria was seen, and the animal, heretofore of correct 
habits, began to urinate in the living apartments. This tendency 
so increased that he was of necessity banished to the cellar. An¬ 
alysis of the urine showed grape sugar in large quantities. No 
direct quantitative analysis was made, however. Thirst and ap¬ 
petite were greatly increased. He made use of food previously 
refused. Emaciation, which appeared after the polyuria, was 
rapid and complete. He lost interest in his surroundings and 
appeared drowsy, but at no time was there coma. Morphia sul- 
pliatis was given in two-grain doses, each 24 hours, without ef¬ 
fect, and finally at about the fourth or fifth month from begin¬ 
ning of polyuria, he was chloroformed. Autopsy showed great 
emaciation, thyroids large walnut size, cystic but not cancerous. 
Thoracic organs normal. Pancreas large, hard and nodular, and 
on microscopical examination seemed to be permeated by medul¬ 
lary cancer, most cells being of the columnar type ; metastasis 
in the lymph glands, liver and stomach. In other respects the 
viscera were normal, except the liver, which was fatty.” 
In these reports, incompletely as they are reported, owing to 
the place where the cases were presented and I having at the 
time no idea of presenting them, there are, nevertheless, several 
interesting points to be noticed. 
1st. I11 all cases grape sugar was present. 
2d. The animals were all aged and fat. 
