ACETANILID (OR ANTIFEBRIN). 
845 
given often and in full doses, and on change of treatment the 
temperature would fall. This was noticeable in typhoid con¬ 
ditions. Acetanilid, I find in sthenic fevers, is one of our most 
reliable drugs for reducing the temperature, and, it would seem 
to often shorten their duration. In debilitating or asthenic dis¬ 
eases, it has little or no effect on the temperature or general 
course of the disease. • In these diseases, when used, there is 
great depression and danger of collapse. Good results are 
claimed from its use in rheumatism, epilepsy, gastralgia and 
sciatica, etc. 
In the winter of 1892 and 1893, I collected a few notes of 
cases treated by myself with acetanilid. While they are not as 
full and complete as I wish they were, they will help to illus¬ 
trate its action, etc. 
Case No. 1 .—Temperature 107-J 0 ; fall in less than 24 hours 
to 102 0 , or fall of 5 0 . 
Case No. 2 .—Temperature 104° ; fall in less than 24 hours 
to ioo| c , fall of 3f° 
Case No. j .—Temperature 107° ; fall in less than 6 hours 
to I0 5t°> fell i t° 5 first d a y> fell in less than 24 hours to 104°, 
fall of 3 0 ; second day, fall to 102-f 0 , fall of i|° ; third day, fall 
to 100J- 0 , fall of if°. 
Case No. 6 .—Temperature 105° ; fall in 24 hours to ioof°, 
fall of 4|°. 
Case No. 7 .—Temperature 104^° ; fall in 24 hours to ioo|°, 
fall of 4 0 . 
Case No. 8 .—Temperature io6f° ; fall in 24 hours to 104°, 
fall of 2f° ; second day, fall to ioi|°, fall of 2f°; third day, fall 
to ioof°, fall of i°. 
Case No. p .—Temperature 103° ; fall in 24 hours to ioo°, 
fall of 3 0 . 
Case No. 10. —Temperature 105° ; fall in 24 hours to 103°, 
fall of 2 0 ; second day, fall to ioo°, fall of 3 0 . 
Case No. 11 .—Temperature 105° ; fall in 5 hours to 104-J 0 , 
fall of |° ; fall in less than 24 hours to 102 J-°, fall of 2f 0 ; nor¬ 
mal on the sixth day. 
