188 
EDITORIAL. 
life of the germ lies the only means of establishing on a solid basis the rules of 
an efficacious prophylaxy of actinomycosis, whether in man or in animals. 
Malleine in the Diagnosis of Latent Glanders.— 
How often have veterinarians been embarrassed in the pres¬ 
ence of an animal possessing a symptomatic resemblance to 
glanders, and yet with such a want of positiveness in its mani¬ 
festations that the question “ whether it is truly glanders” 
had almost to remain unsolved. 
And yet how many means are at his disposal of which he 
may avail himself, as aids in the solution of the question, 
among which are the various inoculations of other animals, 
from the small guinea-pig to the dog, the horse or the donkey. 
But to make such a system of inoculation available, something 
to inoculate becomes necessary, such as the various discharges, 
pus, glandular tissue, etc.; and how often are they absent? ' 
There are cases where the disease is localized in the lungs, 
and there is nothing externally visible, and in these cases 
what is to be done ? 
By the discovery of tuberculine, one fact was established, 
which, if applicable to the virus of other contagious diseases, 
would prove of great value. 
This principle was that the products of secretion of the 
tuberculous bacilli, when cultivated in vitro , have a specific 
and altogether special elective action, upon the organic lesions 
caused by this bacillus. 
If this action existed, was it peculiar to the tuberculous 
bacilli, or did it not exist as well for the pathogenous microbes 
of other diseases ? It is an importont question, and it seemed 
to be answered in respect to glanders in the affirmative. 
Two Hessian veterinarians, Kolinng and Hellmann, were 
the first to announce the result of their labors in the ob¬ 
taining from the extracts of cultures of glanders the malleine, 
which they claimed was capable of an action upon the lesions 
of glanders similar to that of tuberculine upon the lesions of 
tuberculosis. 
Malleine is the glycerinated extract of the cultures of the 
bacillus of glanders, and according to the veterinarians re¬ 
ferred to, a subcutaneous injection was followed in several 
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