444 
E. A de SCHWEINITZ and F. L. KILBORNE. 
rounded (not nodular) left submaxillary gland, with a histor 
of coming from a stable from which two horses were remove' 
and condemned for glanders September 21, 1891. From thi 
date until Feb. 13, 1892, the mare continued in excellent cor 
dition, and the best of spirits, with no perceptible change i 
the above symptoms, although freely purged with aloes tw 
or three times during the period. Two days after the firs 
injection there appeared a slight nasal discharge, followed b 
an attack of acute glanders, the animal dying March 26th. 
Guinea pigs were inoculated from farcy buds, or with th 
nasal discharge from horses Nos. 7, 20, 23, 25 and 26, the pig 
so inoculated all contracting glanders. 
The healthy horses used, Nos. 8, 9, 11, 12, 13, 15, 16, 1; 
18, 22, 24, 27, 29, 30, 33, 36, 37 and 38, were in general i 
good condition at the time of the experiment. 
The glandered horses, except those with a high temper; 
ture at the time of the injection (Nos. 34, 35 and 39,) a 
showed a marked rise in temperature in from four to eigb 
hours after the first injection, and usually reached the max 
mum in from ten to sixteen hours after the injection. Furthe] 
there was in all cases a characteristic, very tender, abrup 
swelling at the point of the first injection, and also at a 
subsequent injections, except in Nos. 19, 20 (ninth injectior 
and 34, generally beginning to appear two to four hours afte 
the injection, continuing on the next day and increasing i 
size for from one to three days, disappearing again three t 
nine days after the injection. 
Some of the healthy horses showed a slight rise of ten 
perature (No. 8 a marked elevation) upon the first injectior 
but only in one instance, horse No. 38, did this rise persist 0 
the second injection. This latter horse has unfortunatel 
been lost sight of, and sold. It was, to all appearances, fre 
from disease when hired for the injection, but the rise cl 
temperature upon two successive injections would look su: 
picious, although it did not show the characteristic swellin 
of glanders after either injection. In healthy horses, in no it 
stance was there very marked swelling at the seat of the ii 
jection of doses not exceeding 1 c.c. of the mallein. When 
