638 
REPORTS OR OASES. 
five years old. She was taken sick after a severe exposure. 
A veterinary surgeon was called, and found among other pa¬ 
thological conditions a temperature of 107°. The diagnosis 
of pleuro-pneumonia was given, and some of the more common 
antipyretics administered—aco >ite, belladonna, spirits of ac. 
tenit., pot. mt. and liq. ammon. acetat., etc., but all without the 
effect of reducing the temperature more than half a degree. 
In consultation an unfavorable prognosis was given, as it 
seemed evid nt that the animal must die, but large doses of . 
quinine were suggested, and it was tried ; five drachms were 
given in the evening, and the thermometer registered 106 0 
the following morning. The dose was repeated in the morn¬ 
ing, and the following day the temperature fell to 102.5 0 . 
Tonics and stimulants were then given. The appetite re¬ 
turned, and tne animal made a rapid and complete re overy. j 
This was a case of double pleuro-pneumonia. 
The second case was a bay gelding five years old, the 
property of the writer ; was noticed to complain slightly, but 
ate well; temperature 104° ; a few d^ses of aconite, belladonna 
and nitrous ether soon reduced it to 102^-°, when we were 
called away. Upon our return, ten hours later, the ther¬ 
mometer showed 1071°, with a well marked case of pneumo¬ 
nia. Quinine in four to six-drachm doses once a day soon 
brought a gradual but permanent reduction of temperature, j 
and complete recovery. 
Four other cases might be reported with same result, but 
these two will serve to show the use of large doses of quinine. 
We believe it is best to give but one dose in the twenty-four 
hours, and hat about seven hours before the daily maximum 
temperature. By so doing hyperpyrexia is prevented, and 
the morning remiss on of temperature is f longer duration 
and greater in degree. The i.se of antipyrine, antifebrine, 
antikamnia have the effect to lower temperature, but only for 
a very short period of time, and their depressing effects upon 
the heart, especially in the advanced stages of this disease, 
are not to be desired. 
