298 
EDITORIAL. 
Professor Nocard, as shown in an article in last month’s 
Review, has given to malleine the attention which it de¬ 
serves. He has experimented with it so largely, and so fully 
stated the conclusions he has reached, that there can no longer 
be any good reason alleged for ignoring its claims in cases 
of suspected glanders, or those in which the symptoms may 
be of a latent character, and have not yet arrived at the stage 
of manifest development. The Archives de Medecine Expert - 
mentale contains an article by Mr. A. Babes, of the Bacterio¬ 
logical Institute of Bucharest, which includes some still more 
important facts. He also had discovered a malleine, but as 
its action differs somewhat from that discovered by Heilman 
and Preusse, he has given it the name of morvine. 
Without entering upon the consideration of the modes of 
preparation of this substance, and only for the present notic¬ 
ing the fact that numerous experiments have been made by the 
author, we present the conclusions of Mr. Babes as possessing 
great value in their relation to the future prophylaxy and 
therapeuty of glanders. 
ist. The bacillus of glanders produces chemical toxic and 
vaccinal substances. 
2d. These are obtained by precipitation in alcohol at 86°, 
or by saturation with the sulphate of ammonium or of mag¬ 
nesium, or again by precipitation in a mixture of absolute 
alcohol and ether, or of the filtrate of the cultures in bouillon,, 
or of that of the emulsion of the cultures on potatoes. 
3d. The method of precipitation in absolute alcohol and 
ether is preferable in view of the rapidity of the process, as; 
well as of the purity of the substance thus freed of toxic 
ptomaine. 
4th. These substances have a thermogeneous and toxic 
action, stronger than the tuberculine of Koch. They have a 
close analogy with enzymce. 
5th. They do not give rise to local reaction, though a fever 
occurs, more or less temporary, according to the species of the 
animal, and convulsions have been sometimes observed. Re¬ 
peated strong doses become fatal with nephritis and maras¬ 
mus. They never give rise to glanders. 
