EPITOME UPON MALLEINE INOCULATIONS. 
675 
He gives directions that when, following malleine injections, 
the temperature advances beyond 3.6° F., the animal may posi¬ 
tively be asserted as glanderous ; when, however, the thermometer 
registers an advance below 1.8° F., there is a possibility of an 
extraneous cause other than malleus. In all of those cases where 
the temperature deviates below these two grades, namely i.8° 
and 3.6°, the evidence is not conclusive, but the observations 
should be proceded with. 
In a second communication {Bulletin de la Societe Centrale de 
Medicine Veterinaire , 28 April, 1892, Recueil , 30 Mai, 1892), 
Nocard relates another interesting case. The same exhibited in¬ 
duration of the lymph glands and circumscribed areas of hard 
swellings in the subcutaneous tissue, which were filled with sup¬ 
purative contents. When the latter pus was inoculated into 
guinea-pigs and spread upon various soils, the result was negative 
in so far as propagation of the glanders bacillus was at stake. 
Nasal discharge absent, and only in the interior of the nose small 
adhesions of dried mucous were visible. 
Subsequent to the malleine administration the temperature 
increased from ioi° F. to 106° F., and the course was a typical 
one ; an immense cedematous, hot and painful swelling was re¬ 
marked at the point of injection, accompanied by a chill. By 
repeating the inoculation of the pus from the skin swellings, the 
result was again void. 
A second application of the lymph placed beyond all reasona¬ 
ble shadow of doubt the fact that the horses were glanderous. No¬ 
card, in order to nullify the negative evidence of the guinea-pigs, 
etc., made a subcutaneous injection of 0.25 pilocarpine, and 
ordered the subject to be exercised with the idea of increasing 
the nasal discharge. The serous excretions from the nose he 
used upon guinea-pigs, and obtained notoriously positive results. 
The question here involved had to do with the nature of the 
pus contained in the cutaneous enlargements. Transplanting of 
the same upon horses, cattle, goats, etc., showed it to be neither 
horse-pox, glanders, nor adenitis. As a direct sequence then, 
from the promises offered, it is to be affirmed that a glanderous 
horse can fabricate a healthy pus, and that glanders is a progress- 
