koch’s method with tuberculosis. 
123 
the whole number treated with the sterilized virus, twenty 
died and only two resisted the disease when subsequently 
exposed. The following gives the results in tabular form : 
4-3 
d 
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£ 
v 
a 
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r 2 
2 
3 
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2 
2 
2 
4 
3 
2 
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p 
Days. 
8 
5 
5 
5 
2 , 2 , 2 
2 , 2 , 
2 
3 
3 
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d ® c 3 
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18 cc. 
19 cc. 
20 cc. 
20 cc. 
20 cc. 
33.5 cc. 
25.5 cc. 
18 cc. 
40 cc. 
33 cc. 
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03 © 
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a o 
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d 
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Days. 
10 
15 
22 
57 
22 
8 
10 
8 
4 
4 
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d 
o 
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Fed diseased 
Intestines of 
Pig. Put in 
Infected Pen. 
Put in 
Infected Pen. 
ii 
ii 
ii 
ii 
ii 
ii 
it 
ii 
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3 
2 
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2 
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Days. 
10-17 
31, 98, 113 
*14, 19 
29, 83 
34 
15, 19 
13, 15 
18, 15 
13, 19, 39 
19, 19, 
15, 16, 18 
18 
18 
There are some points to be noted in explanation of the 
terrible mortality. 
First: The excess of the sterilized virus used, from 18 cc. in 
two doses in eight days to 40 cc. in two doses in three days. 
Because a pig suffering from hog cholera has a great excess of 
these poisons in its system it does not follow that the amount 
is essential to secure immunity. The single vaccine vesicle 
protects the average system. Further, in a disease which, 
like hog cholera, produces congestion and even necrotic ul¬ 
ceration of such vital organs as the intestines and mesenteric 
lymphatic glands, the ptomaines are likely to endanger lesions 
of the parts that may prove lasting, and the embryonic tissue 
in such lesions would be especially open to colonization bv 
the microbe. We see an example of this in the predisposition 
to tuberculosis where there is any inflammation of the air 
passages. It is notorious that after passing through hog- 
cholefa a pig rarely thrives. It is desirable, therefore, to use 
small doses only of this chemical poison for the pig, and to 
avoid, if possible, the production of lesions which would vir¬ 
tually predispose to the disease. 
