140 
J. F. PEASE. 
for that purpose in the river bottoms on the Missouri side, 
where the river annually overflows. The people in this dis¬ 
trict suffer extremely from malaria, and it is not unknown in 
human practice to have cases of malaria assignable to the 
housing of potted plants that have been transplanted from a 
miasmatic soil. 
The position may be untenable, but nevertheless I believe 
these two cases to have been malarial in their origin, and to 
have been induced by the constant presence of the poisonous 
miasm brought in by the bottom-grass, and perhaps finding 
further means of development in the moisture of the voidings. 
Under this conviction, I had the stalls thoroughly cleaned out 
and fumigated with chlorine, thus including bedding that was 
stored away overhead, and there has been no recurrence of 
the trouble. 
The principal symptoms which these cases have in com¬ 
mon, are about as follows : A more or less severe rigor; 
followed by fever, loss of appetite, and very evident headache ; 
disordered action of the liver, as evinced by yellowed mucous 
membranes; the temperature running to io5 Q and io6° F., 
and dropping rapidly to near the normal, only to return to its 
former height; and the absence of any definite signs of in¬ 
flammatory trouble to account for the high temperature. 
It might be objected to this diagnosis that these appear¬ 
ances are those of influenza or catarrhal fever. I would answer 
that influenza is a continuous fever, and thus it differs from 
this, as “la grippe” differs from malaria in human practice. 
But the therapeutic proof of its relationship to human malaria 
seems to me the strongest fact concerning it. 
While veratrum viridi, digitalis, and acetanilid control the 
height of the fever to some extent, or temporarily, and regu¬ 
late the pulse with a greater or less degree of certainty, 
nothing seems to put such a quietus on to the returning par¬ 
oxysms as quinine. And it must be given in rather large 
doses— 3 ij to 3 iv. to be effectual, or in rapidly repeated 
doses, so as to obtain the accumulated action of the doses. I 
believe a physic in almost all cases would prove beneficial in 
unloading the portal system and increasing the absorption of 
