204 
KENELM WINSLOW. 
in veterinary practice ; the respiration is slowed, the heart 
stimulated, and temperature reduced. 
Moderate cold applied locally has also a sedative and be¬ 
numbing effect; the vessels become constricted, tissue meta¬ 
morphosis is diminished, the parts are constringed, and swell¬ 
ing is reduced. Suppuration and sloughing if they occur, 
progress but slowly. The writer has often seen abscesses 
treated unwittingly by ice bags, when the pus was turned 
out of the consistency of ice cream, and the whole nature of 
the process was literally that of a very “ cold abscess.” 
The consideration of the more remote effects of cold will 
be deferred until later. 
Antipyretic treatment, with which we will mostly deal, 
may be classed for convenience into three divisions, depend¬ 
ing upon the three factors concerned in calorification in the 
body. The afore-mentioned factors are ; heat production, 
heat dissipation, and heat regulation. These elements .are 
controlled by nervous centres whose exact localization is as 
yet undetermined. 
Heretofore reliance has mainly been directed to increas¬ 
ing heat dissipation in fevers. This has been accomplished 
in great part through the agency of diaphoretics, combined 
with the use of cardiac sedatives or general stimulants as 
the case demands, and such has been the classical method of 
symptomatic treatment in fevers. On the other hand, the 
more modern or “ true ” antipyretics influence the calorifa- 
cient centres to lessen heat production. 
The employment of these recent synthetic compounds, of 
the so-called aromatic series, seems to be on the wane. Their 
usefulness has been said by one author, seemingly of agnos¬ 
tic tendencies, to consist in enabling animals to die with a 
normal temperature—no great satisfaction, surely, to the un¬ 
professional owners of our patients. 
Finally, we have such agencies as cold irrigation, and 
other applications, which not only directly and physically 
abstract heat, but improve and affect the heat regulatory 
functions, and apparently have a much deeper and farther 
reaching action than any other antipyretic measure. 
It has been proved that the wonderfully beneficent effects 
