214 
RICHARD MIDDLETON. 
It may be upheld by some, that I had to do with spasmus 
glottis, or an oedema of the glottis. The occurrence of the 
former in our patients is yet to be proven; and the charac¬ 
teristic tone which accompanied respiration, as well as the 
sudden disappearance of the dyspnoea would certainly not 
speak for oedema glottis. (Edema of the glottis cannot de¬ 
velop suddenly, without previous inflammatory changes, and it 
cannot, within ten minutes suddenly disappear, without in¬ 
fluencing the health of the animal. The tone was not a 
whistling or rattling, as accompanies suffocation symptoms, 
and which rapidly terminates fatally, but a regularly made 
noise both upon in- and expiration. I do not believe the 
therapy had the least effect upon the course of the dyspnoea. 
PILOCARPINE IN TETANUS, 
Translated by the same. 
Dr. Luigi Casati successfully treated three cases of trau. 
matic tetanus in man, by the use of pilocarpinum hydrochlor- 
icum. Two of these were given this drug exclusively, and 
one received it in conjunction with other medicines. Besides 
these results, the same authority succeeded in healing seven 
of nine rabbits that had been inoculated with tetanus cultures. 
In all the cases the recovery followed rapidly, and after a 
few hours nearly all the symptoms had vanished, the trismus 
disappearing last. 
From these observations, Casati came to the conclusion 
that pilocarpine was the most powerful therapeutic agent 
against tetanus; further, that it was the best, if not the only 
extant antidote for the ptomainic excretions of the tetanus 
micro-organism. 
Considering the circumstance that the treatment of te¬ 
tanus in the horse, up to the present time, has been exceed¬ 
ingly speculative and uncertain, and that one can hardly 
decide from a single trial, I took occasion to institute a series 
of experiments with the remedy so highly praised and rec¬ 
ommended by Casati. 
At sundry times within a short period, there have come 
