PILOCARPINE IN TETANUS. 
215 
under my care six horses suffering from tetanus ; all of which 
I subjected to this treatment, with the result that five termin¬ 
ated fatally, and one recovered. I am not inclined to increase 
the list of trials with the alkaloid, and I desire, therefore, to 
be allowed to make a detailed report upon these six cases. 
I. Three and a half year old, medium weight, draught 
mare, well nourished. According to the unreliable testimony 
of the attendant, the same had received a wound upon one of 
the fore limbs ; upon examination only a few hairless spots 
could be detected about the fetlock. The course of the case 
was slow, and at no time was a well defined trismus present. 
After receiving chloralhvdrate in the drink water, and asther 
sulphuricum in the rectum three times a day—the same treat¬ 
ment being pursued throughout six days—there was no bet¬ 
tering of condition. On the eighth day the patient was given 
0.4 g. of pilocarpine dissolved in 5.0 g. aqu. distill, subcu¬ 
taneously. The characteristic working of the medicament 
commenced within a few minutes and lasted one hour; sali¬ 
vation, diaphoresis and defecation, associated with nervous¬ 
ness, were well defined. 
Respecting the easing of the spasm, I think the same oc¬ 
curred after twenty minutes in the ileospinalis and gluteal 
muscles ; this diminution of the opisthotonous, which alto¬ 
gether was scarcely perceptible, remained some time after the 
disappearance of the symptoms caused by the injection. O11 
the next day the muscular cramp had its original intensity; 
an improvement could not be noted. On the following day 
symptoms of a broncho-pneumonia were detected, and after 
this, from the thirteenth to the twentieth days, the asther 
and chloral were resumed. On the twenty-ninth day the sub¬ 
ject was delivered to the owner. There was more or less 
want of agility in locomotion, as well as a slight degree of 
trismus still noticeable. 
II. Nine-year-old light draught mare. Punctured wound ; 
tetanus not in so developed a stage. Received chloral in 
drink water, and 0.4 g. of pilocarpine, injected ; no cessation 
in spasms. On the third, she was given 0.2 pilocarpine 
which induced the usual symptoms, but did not cause a 
diminution of the contraction; during the same afternoon 
