216 
RICHARD MIDDLETON. 
another dose was given and also followed by profuse saliva¬ 
tion, great anxiety and unquiet; animal died ninety minutes 
later, showing increased pulse and respiration. 
III. Six-year-old riding gelding. Punctured wound, as 
in the previous case. This patient also grew worse after the 
incorporation of chloralhydrate in the drink. No abatement 
of the spasms after receiving 0.2 g. of pilocarpine hydro- 
chloricum ; we injected 0.4 g. pilocarpine on the third day, 
and after three minutes observed severe salivation ; after ten 
minutes, defecation and bedewing of the surface with pers¬ 
piration ; very unquiet and excited ; respirations increased in 
number, and became dyspnceic in character, until twenty-five 
minutes after, the case died under symptoms of suffocation. 
IV. Uncertain age, middle weight draught gelding. 
Doses of 0.4 g. and 0.5 g. pilocarpine, subcutaneous, but a 
relapsing of the convulsions even during the strongest work¬ 
ing of the medicament could not be confirmed. On the 
fourth day the animal died with symptoms of suffocation. 
V. Nine-year-old well bred, heavy carriage mare. This 
was the third horse belonging to this owner, which, in the 
short period of a year, had died of tetanus, in the same stall. 
[It is hardly necessary to state that the owner was warned of 
the necessity of removing the floor and earth in this stall, and 
also to disinfect the same with sublimate solution]. 
In the clinic we found the pulse to be 48, respiration 48, 
temperature 100.7° F. (38.2° C); a swelling upon the left fore¬ 
limb, but no wound. A few hours after admittance into the 
hospital, the case received 0.4 g. pilocarp. hydroch., which 
produced great excitement; animal could, with difficulty, re¬ 
main standing ; countenance betrayed great anxiety. It was 
impossible to distinguish the slightest relaxation. The ap¬ 
proach of the attendant called forth the severest paroxysms, 
so that the clysters of 60.0 g. of tether were only given by 
the greatest care. Death came at midnight of the second 
day. Post-mortem showed a sero-hemorrhagic inflammation 
of the podophyllus tissue upon the sole of the left anterior 
foot. The exudate, when inoculated in experiment animals, 
produced tetanus. 
VI. Very old and thin experiment mare. Inoculated with 
