394 
RICHARD MIDDLETON. 
Pilocarpinum Hydrochloricum. Excites practically all 
glands to increased activity, wherefore it is endorsed as a 
diaphoretic, sialagogue, expectorant, diarrhoeicum, etc. Ac¬ 
cording to Ellenberger, perspiration in the horse follows 
doses of gr. vii-ix, and salivation is seen from gr. §-i. Large 
doses induce pulmonary oedema ! Moller advances this med¬ 
icine as a stimulant to the rumen in tympanites. The dose 
for cattle is gr. ii-iii; for sheep, gr. f. Signol used pil. 
hydrochl. much in ascites of the horse ; he introduced first 
gr. iii p, then gr. v, and finally gr. vi p. Klemm applied gr. 
xii in subacute cerebritis, and gr. xv-xviii in immobility ; he 
covers the patients with blankets, which were gradually re¬ 
moved after twelve hours. 
Hypodermic injections of gr. iii-vii once daily are 
strongly advocated in muscular rheumatism of horses; also 
in laminitis, gr. vii-xi. Such large doses must not be given 
without the antidote (atropin) at hand. We have tried the 
daily application of pil. hydrohl. for its expectorant effect, in 
doses of gr. —i, and can warmly recommend it. 
Respecting purgation, it is advantageous, says Ellenberger, 
to administer physostigmine and pilocarpine together ; the 
idea is to utilize the hydrogogue effect of the latter in aiding 
the peristaltic action of the former. Horses take gr. iss. of 
pil. hydroch., followed by gr. iss. of physostig. Instead of 
pilocarpine one may use muscarine in gr. -J-f doses; the lat¬ 
ter is, however, too expensive. 
Pilocarpin-Eserin. Prepared by Maase in Gorlitz. We 
have frequently convinced ourselves, in the clinic, of the ex¬ 
cellence of the compound as a purgative in colic cases. It is 
dissolved, or comes as a powder in small bottles which con¬ 
tain gr. vii., the proper dose for an adult horse. 
Secale Cornutum. Ergota. Uterine contractions are in 
duced by this drug. From its vaso motor action it may be 
serviceable in hemorrhages. Extractum secalis corunti dyali- 
satum is the proper preparation to use hypodermically, 
Mares and cows require 3 ss.-i; bitches, gr. i~xv. Ergotinum 
Bonjean is also much used in aqueous solution. 
Strychninum Sulphuricum. Exceedingly soluble in water, 
