434 
koch’s tuberculin. 
hen’s egg', and tilled with semi-fluid cheesy pus. The medias¬ 
tinal lymphatic glands were much enlarged and filled with 
dry material. A few miliary tubercles were found on the 
intestines. 
Case No. 4.—This was a red cow, five years old, in fairly 
good condition, temperature varying from ioi° to 102°, pulse 
from 50 to 56, respiration 40, cough frequent. Diagnosis: 
Tuberculosis. 
On Feb. 27th injected 100 mg. tuberculin. Ten hours 
afterward the temperature reached I03f°, dropped to 102° and 
again reached 104°, the second reaction taking place within 
twenty-four hours after injection. On March 3d injected 300 
mg. at 9 a.m. At 2 p.m. the temperature was io 4|°, dropping 
in the next nine hours to 102°, and continuing to fluctuate 
between 102° and 103°, and also remaining permanently higher 
in this animal than before the inoculation. Autopsy : Right 
lung filled with large cheesy deposits and numerous cavities. 
The middle portion of the lung contained large areas of miliary 
tubercle, apparently of recent formation and associated with 
a lobular pneumonia. The left lung presented the same 
general condition as the right. The pleura, both parietal and 
visceral, was covered with masses of tubercular pearls, as 
were also the diaphragm and pericardium ; in short, the entire 
serous membrane of the pleural cavity was covered with these 
growths. The mediastinal glands were enormously enlarged 
and cheesy in character. The larynx and trachea presented a 
well marked case of tubercular disease. Many of the tuber¬ 
cles had broken down into ulcers. The pericardium contained 
several groups of tubercular masses, some of which were 
found on the valves and under the endocardium. In the 
abdominal cavity the entire peritoneal membrane was one 
mass of pearl disease which had extended to the mucous 
membrane of the intestine and had produced numerous ulcer¬ 
ations. The uterus contained a foetus in the right horn, 
several of the maternal cotyledons had broken down, forming 
cheesv masses between the maternal and foetal placentae. The 
corion and cord presented a number of pearl-like bodies of 
various sizes apparently tubercular. The foetus was also 
