EXPERIMENTS WITH GLANDERS LYMPH. 
49f 
use of this agent upon animals afflicted with tuberculosis pro¬ 
duces a series of phenomena which are absent in subjects free 
irom tubercular taint. 
Since diagnosis, by the common methods of auscultation 
and percussion is unreliable, especially so in the primary 
stage, it becomes of extraordinary importance to proceed with 
the development of the multitudinous characteristics of tuber¬ 
culin, and to reduce its application to a definite science. Re¬ 
specting the difficulty oi intra vitam diagnosis, tuberculosis 
is not unlike equine malleus, especially so in the chronic cases 
of occult glanders which are continually being met in old 
orses. Old animals, which at post-mortem show indisputa¬ 
ble lesions of glanders, have, throughout their lives, perhaps 
never exhibited the slightest trace of symptoms referable to 
that disease, probably the only appearances of unthriftiness 
being the short, feeble cough and rough hair. 
It is no wonder, therefore, that of the many cases of death 
occasioned by the presence of glanders in a stable, there have 
been healthy horses slaughtered, under suspicions of also har¬ 
boring the disease ; the protection and preservation of healthy 
animals becomes a very desirable accomplishment from a gen- 
eral economic point of view. 
No remedy has remained untried which afforded the faint-' 
est hope of facilitating the detention and extirpation of glan- v 
ders. Proposed methods are either too ceremonious or too 
untrustworthy to be of practical value; inoculation of animals 
more susceptible to malleus than the horse, application of poor 
culture to horses already afflicted, excision of the sub-maxil- 
ary glands, artificial production of fever and other methods 
have proven unsatisfactory. An agent, to be of use as an aid 
to diagnosis, must produce a specific action in affected animals 
only, and that in a comparatively short time. Such a medica¬ 
ment would be analagous to “ Tuberculineum Kochii,” and 
may only be procured from the glanders bacillus. 
Kalming and Hellmann have busied themselves searching 
such a product, and both have succeeded in securing an im 
crease of temperature after injecting it. 
The first mentioned of these two°investigators is deceased, 
