502 
R. MIDDLETON. 
cliately adjacent to the old nodules in the lungs and liver of 
Nos. 2 and 3 we could discern a lryperaemic zone. On the 
22d of June I inoculated a healthy, black mare, eighteen years 
old, with 0.3 ccm, of lymph prepared from glanderous horses. 
At the time of puncture the thermometer per rectum indi¬ 
cated 100.7° F., pulse 44. 
3 P.M., I00-7 q F., 
p. 40. 
6 “ 100.4°, 
p. 36. 
8 “ 100.2°, 
p. 40. 
9 “ 101.1°, 
p. 40. 
Second inj. 0.5 ccm. lymph, June 23, 
9 A.M., 101.1°, 
p. 40. 
U 
\ 
“ IOI.I°, 
p. 36. 
Third inj. f ccm. lymph, June 
IO A.M. 100.4°, 
p. 36. 
u 
I P.M., IOO°, 
p. 36. 
u 
% 
3 “ 100.4°, 
p. 36. 
u 
7 “ 100°, 
P- 34 - 
u 
9 “ 100°, 
P- 34 - 
June 24, 
7 “ 99 - 6 q , 
P- 34 - 
In this case, as in those mentioned, there also appeared a 
small sensitive and doughy swelling of the submucosa; 
otherwise the general health and deportment of the subject 
did not alter ; its temperature varied only within the range 
of normal deviation, despite the administration of 1.8 ccm.; 
no glanderous lesions were found. At the beginning of 
February malleus appeared in a stable in “ C.”; at first only 
one horse was attacked, but on the 12th of March a second 
was killed affected with it. Toward the end of June another 
animal sickened of glanders ; the same was a gray gelding 
eight years of age. The right submaxillary glands were 
swollen to the size of pigeon eggs, slightly sensitive and mov¬ 
able ; aim of the right nostril covered with amber crusts and 
accommodating a muco-purulent discharge ; septum nasi red¬ 
dened, and well inferior an indistinct ulcer the size of a bean. 
Subject otherwise healthy, moderately cheerful and a rough, 
unkempt coat. On this undoubtedly glandered horse I in¬ 
oculated 0.5 ccm. of malleine on the 30th of June, 8 P.M.; also 
diluted with ten parts of a 1 per cent, carbolic solution ; tem¬ 
perature 100.7° F., pulse 36. 
