HOO CHOLERA 
13 
The hog cholera microbe constantly produces in mice and rab¬ 
bits enlargement of the spleen and numerous foci of coagulation 
necrosis in the liver; the swine plague germ never produces 
these lesions. 
If cultures of the hog cholera bacteria are fed to pigs which 
have been kept without food for a day, they produce the most 
extensive necrosis of the mucous membrane of the large intestine 
and often considerable ulceration of the ilium, invariably causing 
fatal results. Cultures of the swine plague germ may be fed under 
exactly the same conditions without producing the least effect. 
The hog cholera germ inoculated directly into the lung tissue 
produces no hepatization or marked lesion of any kind, but is fol¬ 
lowed by the development of a hemorrhagic or ulcerative case of 
hog cholera. The swine plague germ similarly inoculated pro¬ 
duces extensive and violent inflammation at the point where it is 
deposited. 
These differences in the germs are plain and unmistakable, 
and the lesions found in the two diseases are not less distinct. 
Swine plague is a disease in which the principal lesions are 
found in the lungs; in hog cholera it is the intestines, the lym¬ 
phatic glands, and the spleen which are most conspicuously affected. 
In swine plague the alveoli and small bronchi are plugged 
with cellular masses, the pleura is thickened and may be adherent, 
the lung tissue may become necrosed and caseated. When the 
lungs are affected in hog cholera the lesion is generally of a 
hermorrhagic character, the tissne soft, spongy, and the alveoli 
are full of air. 
Schiitz found no intestinal lesions in the few cases of swine 
plague which he has examined. In a large proportion of cases 
we have found a croupous exudation. Occasionally the mucous 
membrane is secondarily necrosed, in other words, diphtheritic. 
By the sloughing of the superficially necrosed membrane an ex¬ 
cavated ulceration is formed. In hog cholera the ulceration seems 
to be produced primarily by a necrosis of the mucosa, due fp the 
direct effect of the bacterial poison. This necrotic tendency is 
well shown in the liver of mice, rabbits and guinea-pigs. There 
is no cropous deposit seen at any time. The injured mucosa may 
