THERAPEUTIC PROGRESS. 
251 
obtained from its practical use, which will pretty clearly demon¬ 
strate its value and indications : 
A horse received grains of eserine subcutaneously; it 
acted in twenty-five minutes, and produced in the first hour seven 
evacuations, in the second hour seven, the effects passing off in 
two hours and ten minutes. 
A horse received 1J grains of eserine hypodermically, which 
took twelve minutes to act, producing seven evacuations in the 
first hour, and then terminating. 
Another horse received 1J- grains of salycilate of eserine hypo¬ 
dermically, producing a free action of the bowels in one hour. 
This case terminated fatally from ruptured stomach, and thus it 
was demonstrated that eserine could act upon the large intestines 
in spite of the shock to the abdominal nervous system which a 
ruptured stomach causes. 
A pony received 1 grain of eserine hypodermically ; three 
evacuations were produced in fifty minutes, and in eighty min¬ 
utes from the time of injection eight evacuations had occurred. 
The case was a fatal one, the cause of obstruction being due to a 
small diaphragmatic hernia. Had the gut not been nipped so 
tightly, there is reason to believe the increased peristalsis might 
have withdrawn it. 
A horse received a few drops of a solution of eserine into the 
conjunctival sac; it shortly produced contraction of the pupil, 
which lasted fully two days. 
A horse received 1J grains of eserine by injection into the 
trachea; it took seventeen minutes to act, and produced in the 
first hour twelve evacuations, weighing 11 lbs., 13 oz., and a con¬ 
siderable quantity of flatus. The action then passed off. 
A horse received 1 grain of eserine hypodermically; it took 
forty-two minutes to act, and produced only one evacuation in 
one hour, accompanied by a considerable quantity of flatus. 
The same horse received 1 grain of eserine and 3 grains of 
pilocarpine by injection into the trachea; it took twenty-one min¬ 
utes to act. In the first hour, counting from time of injection, it 
produced fourteen evacuations, weighing 30 lbs., 6 oz.; in the 
second four evacuations, weighing 7 lbs., oz., and in the third 
