252 
ROSCOE R. BELL. 
hour two evacuations, weighing 2 lbs., 13^- oz.,—in three hours a 
total of 40 lbs., 10 oz. of egesta. 
In comparing these two cases the value of pilocarpine in addi¬ 
tion to eserine is clearly demonstrated. 
A horse received 1^ grains of eserine by the trachea ; it acted 
in forty-one minutes, and produced in the hour five evacuations, 
and during the second hour four evacuations. The weight was 
unfortunately not obtained, but the quantity of egesta completely 
filled a stable bucket. The case was one of most obstinate con¬ 
stipation, and had received six drachms of aloes previously, which 
ultimately acted at the expiration of the usual time. 
Another horse received 1 grain of eserine with 3 grains of 
pilocarpine by the trachea, which acted in one and a half hours, 
producing in two hours and a half from the time of injection 
eight evacuations, weighing 26 lbs., exclusive of loss. The pilo¬ 
carpine produced its salivating effects in four minutes from the 
time of injection. 
A horse received by the trachea 2 grains of eserine and 3 
grains of pilocarpine, the case being an exceptional one of intes¬ 
tinal obstruction. The drug acted in twenty minutes, there being 
twenty-one evacuations in one and a half hours, which were ac¬ 
companied by the most intense straining we have ever yet wit¬ 
nessed from eserine. The relief to the intestinal pain was con¬ 
siderable, and in a short time it entirely ceased. The case 
terminated fatally a fortnight later, when a disorganized condition 
of intestine was discovered, such as no drug could ever have ben¬ 
eficially affected. 
In reference to its action upon the pulse, respiration and tem¬ 
perature, but few observations were had. If anything, the pulse 
became fuller under its use. The respirations are generally in¬ 
creased, but this is undoubtedly due to the amount of abdominal 
disturbance present. In one case the temperature fell after 
evacuation of the bowels, but the records are meagre on this point. 
RESUME OF SOME OBSERVATIONS ON ANTIPYRIN. 
Kaufmann has been experimenting in the use of this drug, 
both as given through the stomach and when injected subcu- 
