THERAPEUTIC PROGRESS. 
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taneously, his subjects being dogs and horses, and as this great 
febrifuge has been more or less used—and with varying success— 
bv almost every veterinarian,! will give you the deductious made 
by this able observer : 
He linds that by whatever avenue antipyrin enters the system 
it produces irritation of the gastro-intestinal mucous membrane. 
In large doses given by the mouth it often, though not invariably, 
causes nausea and vomiting. To a slight extent it lessens the 
force and number of the heart beats, and slows respiration. In 
still larger doses it produces symptoms allied to those of strych¬ 
nia poisoning, but less marked. Paralysis, beginning in the pos¬ 
terior extremities, sets in, and the gastric juice and saliva are 
strongly impregnated with the drug. The action it has upon ab¬ 
normally high fevers, however, is the most important. In healthy 
• animals very little effect is produced on the internal temperature, 
but even here the effect is more marked than that of quinine and 
its salts. But he considers it a prompt and sure reducer of tem¬ 
perature where it runs high in pneumonia, pleurisy, typhoid fever, 
acute rheumatism, erysipelas, tuberculosis, giddiness and scarla¬ 
tina. 
He gives great preference to the hypodermic method of ad¬ 
ministration, as it has a better action, can be used in smaller 
doses, and less frequently. The best solution is 1 to 50 of warm 
water, and in this strength produces no local nor general bad ef¬ 
fects. In high fever it must be administered in full doses every 
hour until the fever has abated. It is cheap and powerful, and 
Kaufmann thinks it should be substituted in every case for 
quinine. He also claims for it a marked hsemostatic and anti¬ 
putrescent action. A medium-sized dose for the horse by hypo¬ 
dermic injection is 10 grammes ( 3 vj.), and for the dog 1 gramme, 
to be continued hourly until the fever subsides. The dose by the 
mouth is the same, though oftener repeated. 
SUBCUTANEOUS INJECTION OF MUSTARD AS A COUNTER-IRRITANT. 
The employment of mustard as a subcutaneous injection was 
first brought to the notice of the Central Veterinary Medical So¬ 
ciety of Paris by M. Durien, a veterinarian, May 13, 1886. The 
