ANTIFEBRIN OR ACETANILID. 
305 
sequently employed in the human being, and from the numerous 
(nearly 200) compiled reports, I have the following to cite con¬ 
cerning its action: This remedy never fails to reduce the tem¬ 
perature of such suffering with fever, and of all the applications 
made, thus far known, there has been but one instance in which 
the temperature did not fall, but in this case, thallin also had no 
effect. 
“ The dose for human beings is 0.25 centi. to 0.1 decigr. Its 
action is more than twice as powerful as that of antipyrin or 
thallin. It has no disagreeable secondary effects. The tempera¬ 
ture is more rapidly and lastingly reduced in the decrescent stage 
than when the disease is at its acme. The lowering of the tem¬ 
perature sets in two or three hours after its introduction into the 
system, and continues from three to five hours, then, at first a 
slow, later a rapid increase follows in the acme stage until it has 
reached the original height or over. 
“ In the decrescent stage it never reaches the old height of 
temperature again. 
“ In typhus, the temperature could not be kept down perma¬ 
nently, by giving antifebrin in oft repeated doses. 
“ According to Kowacs and other observers, antifebrin reduces 
the pulse and the pressure of the blood; Krueger, however, dis¬ 
putes this. 
“ The dreaded after-effects of other fever-allaying expedients, 
such as profuse perspiration, vomiting, chills, collapse, etc., are 
not manifested in the use of antifebrin. Slight chills (though 
very seldom,) frequent, but agreeable perspiration and diurese are 
met with. The stomach retains antifebrin very well, though 
according to Hinzelman, it operates equally well if brought high 
up in the rectum, from whence the action is speedier (after one 
hour) if the dose be of the same strength. 
“ In the treatment of wounds, Krueger regards antifebrin as 
a most powerful disinfectant, applied in the form of powder, or 
dissolved in ether or collodium, or in gauze. 
“Riese claims to have observed a specific action in poly¬ 
arthritis. 
Fiirbringer has administered it as high as 6 gramm into the 
