306 
J. C. MEYER, SR. 
blood vessel of dogs and continued this large dose for seven days, 
before indication of poisoning set in; these appeared as paralytic 
manifestation, weakness of the hind part, syncope, cramp and 
death. 
“ Reckoning the weight of the body on the kilo, the death 
dose for a human being would be 30 gm.; 0.25 to 0.5 already act 
antifebrile. Oft-repeated smaller doses cannot be recommended, 
inasmuch as such scattered doses are entirely lost in the organ¬ 
ism. Using this article in the clinic on animals, I found as a rule 
the above accounts substantiated. 
“ Certainly the results in our domestic animals cannot always 
be established, the information as to the subjective feelings being 
wanting, and slight after-affects overlooked. 
“ The supposition that since it requires 0.25 centi. to 0.5 
decigramm antifebrin to generate antifebrile action in a human 
being weighing 140 pounds, 5 to 10 gramm would be necessary 
for a horse weighing 1,000 pounds, has been proven incorrect. 
A horse requires much larger doses if the expedient is to act as an 
antifebrile. 20 to 25 gm. doses were very often effectual. 30 gm. 
are most reliable. 100 gm. were administered to an anatomical 
subject in one day without result. Frequently it was given with 
digitalis and small doses of calomel. 
“ In all instances the action of antifebrin set in. In a few 
cases, when the result was not wholly satisfactory, it was shown 
that the medicine was not administered properly. In animals at 
death’s door, the lowering of the temperature was traceable for a 
short time, to a slight degree. 
“ The value of the expedient lies solely in its antifebrile action. 
As long as the fever is reduced, the patients feel better. How¬ 
ever, according to my experience, it is not a specific against fever- 
creating causes.” 
Gentlemen, the above account prompted me to give this re¬ 
markable agent a trial, and in many cases in which a lowering of 
the temperature was desired I gave the antifebrin and in the 
main points I found Dr. Hoffmann’s statement verified; in fact, I 
observed, after administering the remedy, especially in enzootic 
pleuro-pneumonia, considerable sudation in some patients, in 
