374 
PATHOLOGICAL ANATOMY. 
tine and with serum. The first were negative, but the second 
were at one time very rich in the bacilli of tetanus, and these 
were used to inoculate on the flat of the thigh a donkey, which 
after twenty-two days showed lock-jaw and died. Material was 
obtained from him for the inoculation of eight rabbits, and of 
these two remained healthy, two died of scepticeemia without 
tetanic symptoms, and the last four died of lock-jaw. 
The conclusions reached are, 1st, that the experimental tetanus 
of equines seems to differ in nothing from the spontaneous dis¬ 
ease ; 2d, that an actual identity exists between the spontaneous 
and the experimental disease, and 3d, that tetanic virus may be 
found in the earth and in dusts .—Revue Scientifique. 
PATHOLOGICAL ANATOMY. 
REPAIR OF ARTERIES AFTER LIGATION. 
By J. Collins Warren. 
The author has studied the mode of the cicatrization of arte¬ 
ries, from the first step to the final conclusion of the reparative 
process, and from numerous experiments upon horses and dogs, 
has concluded that the process of repair is different from that 
usually described and accepted by classic authors. This process 
is divided by him into three periods. In the first, some two or 
three weeks in duration, are included the modifications observed 
immediately after the application of the ligature, and during the 
times of the gradual separation of the arterial walls. The second, 
covering about one month, comprehends the formation of an ex¬ 
ternal and internal callus. The third covers the gradual resorp¬ 
tion of this and the formation of the definitive cicatrix. 
First Period. The complete rupture of the internal and com¬ 
plete or incomplete of the middle coat first occurs; the clot is 
always present, even when antiseptic measures are employed. 
Soon after the application of the ligature, there is an accumula¬ 
tion of leucocytes near it, and the knot of the thread is englobed 
in a mass of embryonary tissue surrounding the ends of the liga¬ 
ture. There is a common proliferation of the elements of the in- 
