456 
H. C. YARROW. 
creatine into the tissues would produce the same effect as venom, 
and the experiments of others seeming to confirm this theory, 
notably those of Bechamp and Baltus in Compt. Rend. Acad. Sri., 
Paris, February and March, 1880, which were as follows: “ In¬ 
jected into femoral of dog three grams of pancreatine at 9 a. m., 
died at 5 p. m. Another case: Bloody faeces, vomiting, emission 
of urine; lived ten days. Some got well.” The conclusions of 
Bechamp and Baltus are that the intra-vascular injection of pure 
pancreatine produces functional symptoms of great gravity, and 
produces death if the injected material is about 0. gr., 15 par kil¬ 
ogrammes of the weight of the animal. Digestion seems to 
diminish the toxic effects of the pancreatine. Injected pancrea¬ 
tine is only partly eliminated by the kidneys, and when found is 
unaltered in character. 
In view of these facts it was determined to try the effect of 
pancreatine on fowls. Through the courtesy of Messrs. Fairchild 
Bros, and Foster, of New York city, the writer was furnished 
with a remarkably pure sample of the extractum pancreatis. 
This was used in solution with distilled water in the following 
proportion: One-half dram of extractum pancreatis to one-half 
fluid ounce of distilled water. 
Nov. 4, 1887.—12:40 p. m. —Injected black pigeon with 25 
minims of pancreatis solution in right thigh. Bird commenced 
to droop at once, feathers ruffled, whether from fright or injury 
by hypodermic needle uncertain. 
2:30 p. m. —Bird seems better. 
Nov. 5.—Pigeon in normal condition, eating heartily. 
Nov. 6 and 7.—Bird entirely well. 
12:29 p. m. —Injected hen No. 2 with 75 minims of solution 
of extract pancreatis (J dram to one ounce of water) in right 
thigh. 
12:35 p. m. —Respiration much quickened, mouth gaping. 
1:30 p. m. —Fowl eating corn, but seemed inclined to lie down. 
Respiration still rather fast and mouth gaping, though not so 
much as at first. 
3 p. m. —Fowl in about the same condition as at 1:30. 
Nov. 9.—Hen seems to be as healthy as ever, and has a good 
appetite. 
