GLANDERS. 
13 
the acute or severe cases, but that they multiply in the blood 
and tissues to such a degree that the poisonous waste products 
given off by them, unless promptly thrown out of the sys¬ 
tem or destroyed, produce fever and other general symptoms of 
disease. 
In the mild or chronic form of glanders these germ poisons 
are not formed so rapidly and the system soon becomes so 
accustomed to their presence and the means necessary lor their 
removal , that they are carried from the body before they pro¬ 
duce any change in the body temperature. 
If then we add to the amount of this poison which the animal 
body is accustomed to handle and throw out without difficulty 
a small amount of artificially prepared mallein we create such a 
disturbance in the system of the animal as to cause the tempera¬ 
ture to increase several degrees above the natural body heat, 
accompanied by usual symptoms of fever and aggravating for a 
time all the symptoms of glanders. 
During the short time since the discovery of mallein it has 
been tested by leading scientific veterinarians in every part of 
the world, and, so far as I have been able to find, no investigator 
has condemned it, but all unite in asserting that its use has at 
least furnished us with an agent by which we can readily and 
safely diagnosis the disease, not alone in suspected cases, but 
in those animals where the most careful physical examination 
can detect no signs of disease. 
Mallein has proven so reliable that it has received govern¬ 
mental recognition in many European countries and its use 
officially advised or commanded. 
In cavalry regiments where glanders had broken out, the 
use of mallein on all exposed horses was made obligatory in 
Germany and Belguim in 1892 and France in 1893. During the 
present year (1894) the use of mallein has been made obligatory 
in Switzerland in all horses, mules and asses, in stables or es¬ 
tablishments where glanders has occurred, and in all cases of 
suspected glanders; and in all cases where the use of mallein is 
followed by a well marked fever and other characteristic results 
