GLANDERS. 
15 
creased, the glands more swollen and the ulcerations in the 
nostrils may increase in size and number. In other instances 
as will be seen later, especially in mild cases, no such evidence 
of increased disease action occurs. On the other hand animals 
free from glanders show none of the above symptoms in a 
marked degree after mallein injection, the temperature rarely 
increasing one degree C, if at all, the swelling at point of in¬ 
jection being small, soft, and not very painful to the touch, 
while the appetite and general appearance remain unaffected. 
Other diseases than glanders do not affect the action of 
mallein, and it has been used on animals, affected with distem¬ 
per (or strangles), disease of the cavities of the face with abun¬ 
dant nasal discharge, botryomycosis (a disease similar to lumpy 
jaw of cattle, affecting at times the legs of horses like farcy) and 
other diseases resembling glanders, but in all cases the injec¬ 
tion produced none of the results found in that malady. 
Again it has been suggested that other substances of a 
similiar character, such as tuberculin (the product of the bacil¬ 
lus tuberculosis or consumption germ) might produce the same 
results when injected into the system of a glandered horse, but 
experiments with tuberculin at least, contradict this view. 
District Veterinarian Walther * of Saxony injected beneath 
the skin of each of three glandered horses o. 3. c. c. each of 
tuberculin without producing a reaction while a like amount of 
the same tuberculin used upon a tuberculous cow produced the 
typical fever. 
In rare cases the use of mallein on animals free from glanders 
has produced a decided elevation of temperature but not in the 
typical manner, for while in cases of glanders the fever usually 
reaches its highest point in from eight to twelve or rarely six¬ 
teen hours, in these rare cases of fever in animals free from 
glanders the high temperature is not generally reached until 
nearly or even more than twenty-four hours after its use. In 
cases of doubt where the elevation of temperature is clear, yet 
♦Deutsche Zeitschrift fur Thiermedicin, Vol. XIX, p. 173. 
