i8 
W. L. WILLIAMS- 
United States Bureau of Animal Industry cite thirty-eight tests 
with mallein (mostly upon glandered horses) either by them¬ 
selves or under their directions, in all cases proving wholly re¬ 
liable. Dr. Pearson,* Professor Veterinary Medicine, University 
of Pennsylvania, experimented with mallein upon guinea pigs, 
some of which were healthy, others glandered ; the latter re¬ 
acted strongly. 
Dr. Nuppe, in an unpublished paper, reports mallein tests 
upon about three hundred horses in large establishments in New 
York city where glanders had long been prevalent, with the re¬ 
sult that several cases of internal or masked glanders were found 
and destroyed, putting an end to the ravages of the disease in 
the infected stables. 
In the brief time during which this situation has existed it 
has not been practicable to arrange for experiments with con- 
tagious diseases at the station, so that our opportunities for 
making mallein tests have been upon farms where the disease 
existed, a condition which has necessarily restricted our experi¬ 
ments within very narrow limits. Our experiments with mallein 
were confined to two stables in which glanders had existed for 
some time and the mallein test was applied to eight animals. 
The results of these eight tests may be briefly summarized, as 
follows : 
NO. 
DATE. 
av’rage tem¬ 
perature 
DAY PREVIOUS 
TO TEST. 
TEMPERATURE 
AT TIME OF 
INJECTION 
OF MALLEIN. 
HIGHEST 
TEMPERATURE 
AFTER 
INJECTION. 
NO. OF HOURS 
AFTER INJEC. 
WHEN HIGH’ST 
TEMPERATURE 
OCCURRED. 
INCREASE OF 
TEMPERATURE 
IN DEGREES 
CENTIGRADE. 
I 
Feb. 
17, 1884 
37-2 
36.7 
39.7 
12 % 
3 -° 
2 
1 4 
4 4 4 4 
37-9 
36.2 
39-7 
10 
3-5 
3 
4 4 
4 4 44 
3 6 -9 
37-3 
40.2 
10 
2 -9 
4 
4 4 
4 4 4 4 
3 6 -9 
38.0 
10 
1.1 
5 
4 4 
44 4 4 
3 6 -9 
39 -o 
12 % 
2.1 
6 
July 3, 1894 
38.3 
37-7 
40.6 
12 
2.9 
7 
4 4 
4 4 4 4 
38.2 
37-5 
39-7 
12 
2.2 
8 
4 l 
4 4 4 4 
38.1 
37-3 
38.4 
12 
1.1 
Nos. i, 2, 3 and 5 were all clearly affected with glanders and 
so pronounced before using the mallein. As will be seen all 
* Journal Comparative Medicine, September, 1891. 
