IS TUBERCULIN, AS ORDINARILY USED, TOO DELICATE A TEST? 
57 
Diseased... i—Slight. 
Healthy. 2 
Did not react, but slaughtered. 3—Extremely bad. 
Did not react, but died a week later. I—Extremely bad. 
As illustrating the different effects of small and large doses 
on animals in different stages of disease, I ask careful attention 
to the following chart. It is only an example, on a small scale, 
of what has been my experience generally : 
DR. HENRY COLT HERD, PITTSFIELD, MASS. TESTED JUNE 5, 1894. 
NORMAL. 
No. OF Cow. 
12 P. M. 
7 A. M. 
II A. M. 
2 P. M. 
4 P. M. 
6 P. M. 
1 
2 
3 
102 
103 
I02| 
I 03 | 
103 
ioo£ 
102 
io6£ 
IOO§ 
ioif 
io 6 £ 
IOOf 
H M H 
0 0 0 
0 ON W 
Ctifk otw 
IOl| 
1055 
IOO 
Not tested. Had calved that day- 
Great enlargement bronchial and 
mediastinal glands; abscesses 
both lungs. 
4 
5 
6 
7 
100 
101 
IOlf 
not tested. 
IOI 
IOl| 
102 
102 5 
1035 
i° 4 i 
O 0 
M M 
1022 
103 6 
Slightly diseased, lungs or liver. 
Had calved six days before. 
Dose, two-thirds of a minim (Koch’s). 
TESTED JUNE 21, 1894. 
NORMAL. 
No. of Cow. 
8 A. M. 
4 P. M. 
6 P. M. 
8 P. M. 
IO P. M. 
I 
ioif 
IOI§ 
102! 
IOI§ 
IOI 
6 
IOl| 
102 }} 
105 
I 05 § 
1045 
Disease both lungs and bronchial glands ; 
posterior third right lung consolidated; 
section presents appearance of typi¬ 
cal case of recovered contagious pleuro¬ 
pneumonia; large abscess on liver. A bad 
case. 
/ 
Dose, two-thirds of a minim (Koch’s). 
TESTED JAN. 6, 1895. 
NORMAL. 
No. OF Cow. 
IO.3O P. M. 
8.30 A.M. 
IO.3O AM 
12.30 P M 
2 P. M. 
1 
2 
4 
IOO§ 
ioi£ 
iooj( 
1061 
I° 5 s 
1021 
1072 
1042 
I0 4 r. 
106I 
I02g 
Slight enlargement bronchial glands, dried 
up and calcareous. 
Bronchial glands slightly diseased, dried up 
caseous condition, milliary tuberculosis of 
liver. 
Glands slightly diseased, caseous nodule oa 
right lung size of a hazel-nut. 
7 
TOIg 
102 
I02| 
102 % 
H 
O 
H 
OUO 
Dose, three (3) minims (Koch’s). 
It will at once be noticed that cows 3 and 6 readily re¬ 
sponded to a small dose of the agent, had a high elevation of 
