336 
EXPERIMENTAL PATHOLOGY. 
mal makes a voluntary effort, then it is spontaneous and in¬ 
termittent, and then continues with spasms connected with the 
obtusion of the animal, and then convulsions and death. 2. In 
the chronic state, one does not observe the influence of the 
regim as observed in acute cases by Breisacher. 3, The de¬ 
velopment of the symptoms has no marked influence upon the 
excretion of the carbonic acid. 4. The lowering of the tem¬ 
perature does not bring on an elevation in the excretion of 
the carbonic acid as it normally happens. 5. The thermic 
production varies much more than in the normal animal. 
But it is especially the apparatus of thermic production which 
is altered. There are vascular modifications of the skin ; the 
ears of the cat are at times congested, at others anaemic. 
These vascular changes are somewhat similar to those of the 
strumiprivarous cachexia. T. he second cause is the alteration 
■ of the skin, the dropping of the hair. The alteration of the 
skin and the lowering of the temperature belong also both to 
the cachexia, which are wanted in cats. The fact to be 
obliged to regulate the temperature only by means of the 
productive apparatus must bring a consumption. Patients 
suffering with myxodema always complain of cold. And 
.again, extreme heat is as insupportable to them as cold. The 
role of the thyroid in the thermic regulation is but one of the 
aspects of its general action, and this is only indirect.— Ibid. 
OF THE ABSORPTION OF MICRO-ORGANISMS BY FRESH WOUNDS. 
By C. SCHIMMELBUSCH. 
The author has made experiments to study the possibility 
of disinfecting a recent wound made on an animal and artifi¬ 
cially infected. He failed, no matter what means of disinfection 
he used, he could not succeed in protecting a rat or a rabbit 
from general infection when he infected a recent wound with 
the pus of anthrax or the septicaemic streptococcus. 
Trying to find the cause of these failures, Schimmelbusch 
observed that the germs entered so rapidly in the blood that, 
even on operating on the tail of an animal and cutting it off 
five minutes after the infection, yet the germs were already 
in the general circulation. 
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