THE HORSE AS A PRODUCER OF ANTITOXINES. 
395 
le and anticipated very grave symptoms at first. For about 
ne hour, however, the old horse stood motionless, exhibiting 
o reaction beyond a sudden rise in temperature of two de- 
rees. Then he showed, gradually, uneasiness, with an occa- 
ional spasm of the neck and a peculiar arching of the back. 
'Vithin two hours the temperature rose to 104 20 , the horse 
ecame extremely sensitive of touch, and pressure at the point 
f injection in the shoulder produced spasm of the muscles in 
lat region. After three hours, being suddenly approached 
y a stableman, he fell backwards and died within fifteen 
finutes under tetanic convulsions. 
Symptoms still different are produced by the injection of 
treptococcus-toxine. The main effect is an elevation of tem- 
erature of one to two or more degrees, which extends over 
le second or even the third day. The other symptoms be- 
ome visible within three to four hours after injection and are 
ot very marked, but none the less severe. The horse stands 
ither quiet, the head bowed downward, paying no attention 
) its surroundings, or to noise, or to food offered him. He 
smains so for hours at a time and he gives the impression of 
eing a “ pretty sick horse,” as a visiting veterinarian expressed 
the other day. After the fifth injection of this toxine the 
orse showed symptoms of colic pains, looking at his flanks 
id biting them occasionally. 
These are our observations up to date, and, as far as I 
now, the effect of the tetanus-toxine and streptococcus-toxine 
pon the horse have not been published before. Inasmuch as 
lese observations were conducted on a limited number of 
Drses, they are subject to modification, but on the whole they 
ill be found to be correct. The symptoms, as described, 
ill greatly depend upon the preparation of the toxins, the 
srms producing different toxidity according to the soil on 
hich they are cultivated. It is a matter of bacteriological 
xperience to select a material of such chemical composition 
- will produce the highest toxidity, and much depends upon 
^e skill of the bacteriologist. I think some of the toxins, if 
*operly prepared, may be profitably used for demonstrative 
irposes for students, as the effect is so marked and charac- 
ristic. 
