396 
OLOF SCHWARZKOPF. 
After the horses have been inoculated with these toxine 
for a sufficient length of time to endure large doses, and afte 
having fully recovered from the effect of the last injection, 
sample of blood is drawn, and the serum separated unde 
aseptic precautions and injected into experimental animal 
which have previously been infected. If by this experimen 
the serum proves to contain sufficient anti-toxic properties 
large quantities of blood are drawn for the preparation c 
anti-toxine for therapeutic purposes. 
As to the application of the tetanus-antitoxine and strep 
tococcus-antitoxine in veterinary practice, very few, if an) 
trials have yet been made, as these new therapeutic agent 
are of so very recent date. We treated one horse, which wa 
beyond hopes of recovery, with a io cc. dose of tetanus-ant 
toxine, merely to satisfy the owner, who wanted us to tr; 
anything to save the horse. Although this was all the quar 
tity we had on hand and too small a dose, he informed us, th 
morning after the injection, that there was a noticeable irr 
provementin the condition of the horse, but he died the sam 
night. I report this negative result in order to dispel extrem 
expectation. As reports from human hospitals indicate, th 
early application of tetanus-antitoxine, if accompanied b 
proper surgical treatment of the wound from which the infer 
tion started, is bound to result in a cure; with the frequenc 
and gravity of tetanus in the horse, we certainly look towar 
this new therapeutic agent with great hope, and it remains ti 
be seen whether its success in veterinary practice will b' 
equal to that obtained in human medicine. 
Whatever may be the future of serum therapeutics, I shoul 
warn you against too much enthusiasm. Let us cautiousl 
try these new remedies, if they are such, and not give a judp 
ment off-hand, as has already been done by some. Succes 
will alternate with failure, and the supporters and enemie 
will view it from their opposite standpoints. As far as vete: 
inary science is concerned, it is certain to play an importar 
factor in the development of serum therapeutics, and to us, a 
members of this science, it will add greater responsibilitie 
and insure greater opportunities. 
